How Is Herpes (Oral or Genital) Spread? HSV-1 is usually passed from person to person by kissing. HSV-1 can also spread from the mouth to the genitals during oral sex (fellatio, cunnilingus, analingus). If this happens, it becomes a case of genital herpes. HSV-2 is most often passed by vaginal sex and anal sex. Oral herpes is transmitted through direct contact between the contagious area and broken skin (a cut or break) and mucous membrane tissue.

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